Factory
ABOUT US

Founded in 2012, Heyuan Biotechnology is a high-tech enterprise integrating R&D, production and sales.

We specialize in natural konjac skincare products, which are exported to more than 76 countries.

We have professional production lines, clean workshops and multiple international certifications.

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Our OEM & Private Label Product Services

Professional Product Solutions

EXOSOME-FREEZE-DRIED-POWDER-KIT

Composed of phospholipids, cholesterol, etc., protecting internal substances from degradation;

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Anti-hpv Biopretein dressing

TUJINI Anti-HPV Bioprotein Dressing physically blocks viral entry, rapidly reduces viral load, safely helps turn HPV positive to negative, prevents lesions and wart recurrence, and is suitable for both men and women.

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Medical recombinant collagen gynecological gel

A protective and care gel specially designed for women's intimate areas, formulated with medical-grade recombinant collagen. It forms a gentle protective film on the vaginal epithelium, creating a physical barrier to help shield against the colonization and invasion of external pathogenic microorganisms.

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Technical Support & Product Development

Active Ingredient R&D Center laboratory

Active Ingredient R&D Center

Professional R&D of natural plant actives and botanical extracts for skincare innovation.

Biological Polysaccharide R&D Center

Biological Polysaccharide R&D Center

Focus on konjac polysaccharide research with university collaboration for advanced skincare materials.

Exosome Biotechnology R&D Center

Exosome Biotechnology R&D Center

Advanced exosome platform for biomedical skincare R&D and clinical applications.

Core Manufacturing Technology

Plant fiber crosslinking technology konjac sponge

Plant Fiber Crosslinking Technology

Pure natural plant fiber material, zero chemical addition, high water absorption, soft and skin-friendly.

Exosome bioengineering technology

Exosome Bioengineering Technology

Stable drug delivery and targeted effect, improving skincare effectiveness scientifically.

Recombinant collagen technology

Recombinant Collagen Technology

Highly compatible collagen to repair skin and restore skin elasticity.

Strict Quality Control & Certification

TECHNICAL RESOURCES
We strictly follow ISO9001, GMP, ISO22716 and ISO13485 standards. Every batch of biological skincare materials and medical raw materials is strictly tested from incoming materials to finished products, ensuring safety, stability and high efficiency.
GMP clean room for biological raw material production Medical skincare raw material production workshop Biotechnology fermentation tank equipment
ISO standard purification workshop Biomedical product production line Laboratory testing and quality inspection equipment Biotech skincare raw material processing machine
Equipped with professional homogenizers, mixers, spectrophotometers and sterile clean benches, we provide complete R&D, testing and customized production services for biomedical and skincare raw materials.

Global Cooperative Partners

Heyuan Bio Cooperative Partners Collection - Estee Lauder, L'Oreal, Watsons, Unilever

News & Industry Updates

  • Collagen HA Dressings for HPV-Related Skin Lesions & Wound Recovery
    May 14, 2026

    For individuals undergoing treatment for HPV-related skin lesions or genital warts, post-procedure wound care is critical to prevent infection, reduce scarring, and support healthy skin regeneration. Collagen hyaluronic acid dressings have emerged as a safe, effective option for managing these sensitive wounds. At Heyuan Bio, we develop medical-grade dressings tailored to support recovery from HPV-related skin treatments. Why HPV-Related Wounds Require Specialized Care Treatments like cryotherapy, laser ablation, or topical medications for HPV lesions often leave behind raw, irritated skin. These wounds are particularly vulnerable to: Secondary bacterial or fungal infections Delayed healing due to inflammation Scarring and pigmentation changes Recurrence risk in compromised skin environments Traditional dressings may not provide the moist, biocompatible environment needed to support healing in these sensitive areas. Collagen HA dressings address these challenges with targeted benefits. Key Benefits of Collagen HA Dressings for HPV Wound Care Supports Tissue Regeneration Collagen acts as a natural scaffold for new cell growth, helping the skin rebuild healthy tissue after treatment. Maintains a Moist Healing Environment Hyaluronic acid locks in moisture, preventing the wound from drying out and scabbing, which reduces the risk of scarring and discomfort. Reduces Inflammation & Irritation The gentle, hypoallergenic formula soothes redness and inflammation, making it ideal for sensitive genital or facial skin. Forms a Protective Barrier The dressing creates a physical barrier...

  • Meet TUJINI Rose Hydrosol: Pure Rose Water, From Mountain to Skin
    May 13, 2026

    TUJINI Rose Hydrosol  Base Traceability Journey On May 10, 2026, the Damask Rose Base at Shaohua Mountain in Weinan, Shaanxi, was filled with the fragrance of blooming flowers and welcomed a gathering of distinguished guests. The "Trace to Nature · Embrace Purity" Rose Base Exclusive Journey, hosted by the TUJINI brand, concluded successfully. The brand's core product, TUJINI Rose Hydrosol, made its official debut, launching an immersive raw material traceability experience that showcased origin quality and transparent craftsmanship, injecting new momentum into the deep connection between the brand and its partners. This two-day traceability journey (May 9–10) centered on the themes of "raw material traceability, process transparency, and value co-creation." National key partners and high-intention clients were invited to the site to witness the entire journey of TUJINI Rose Hydrosol from fresh flowers to finished product — from early morning flower picking to workshop process observation. Trust was deepened and consensus was built through this integration of nature and professionalism. At six o'clock in the morning, Shaohua Mountain was veiled in light mist with dew-kissed roses, marking the prime harvesting time for Damask roses. Guests wore custom straw hats and carried picking baskets, hand-picking the morning-dew Damask roses under the guidance of professional technicians. The unique climate and soil of Shaohua Mountain nurture roses with rich fragrance and abundant active...

  • Inside Bikoni Visha: A 5,000㎡ GMPc Certified Cleanroom – The Birthplace of Konjac Sponges That Meet FDA Standards
    April 29, 2026

    🏭 Inside Bebevisa: 5000㎡ GMPc-Certified Clean Workshop What we take pride in is not the scale, but the standard. Wuhan Bebevisa Bio-Tech Co., Ltd. operates a 5,000㎡ GMPc-grade clean workshop — the birthplace of every konjac sponge and every sheet mask. ✅ Class 100,000 air purification system ✅ Full-process temperature & humidity monitoring ✅ Automated production lines ✅ In-house microbiological, physicochemical & stability testing laboratory From raw material to finished product, every step is completed in a controlled environment. That's why Bebevisa products meet both EU and U.S. FDA standards. All products are manufactured by Bebevisa, with R&D and sales by Heyuang Biotech. 📍 China·Wuhan Optics Valley Bio-City #GMPc #CleanWorkshop #MedicalDeviceManufacturing #KonjacSponge #Biodegradable #MadeInChina #Bebevisa #HeyuangBiotech #FactoryTour #WuhanOpticsValley

  • boost hpv immunity & support natural clearance
    April 28, 2026

    HPV clearance through body wisdom 80% of women encounter HPV — your immune system holds remarkable power. Evidence meets elegance. 70–90% of HPV infections clear naturally within 1–2 years Low-risk types (6,11) often disappear in 6–12 months, while high-risk types (16,18,52,58) deserve mindful monitoring. The right habits to support your immunity are within reach. controllable factors ✓  Sleep & rhythm ✓ Balanced nourishment ✓  Smoking cessation (2–3x persistence risk) ✓ Stress management Immune‑boosting nourishment   key nutrients Folate & B Vitamin C Vitamin D Zinc Antioxidants 🥬 folate rich: spinach, asparagus, legumes (400‑800 mcg) 🍊 vitamin C: citrus, bell peppers, kiwi (100‑200 mg) ☀️ vitamin D: salmon, fortified milk + sunshine 15‑30 min 🦪 zinc: oysters, pumpkin seeds (8‑11 mg women) 🫐 antioxidants: colourful veg & berries ≥500g/day 🌸 mindful eating tips ✨ reduce ultra-processed & sugar — lowers chronic inflammation ✨ prioritize lean protein (fish, legumes, tofu) ✨ limit alcohol — it dampens antiviral defenses ✨ avoid raw/undercooked food for overall immunity Diet is not a cure, but it profoundly supports immune cells fighting HPV. 💞 Movement & rest Movement rhythm 3‑5x/week · 30‑60 min Aerobic (walk, swim, cycling) + yoga 2‑3x/week + light strength training. Moderate exercise increases lymphocyte counts and accelerates HPV clearance. Avoid overtraining — rest is sacred. Sleep sanctuary 7–9 hours nightly — consistency is...

  • Stop the Itch & Odor — Without Killing Good Bacteria
    April 27, 2026

        🌸 High-tech Enterprise · Certificate No. GR202242007745 Naji Ni New Era of Intimate Care ✨ Medical Recombinant Collagen Gynecological Gel ✨ Adjuvant treatment for vaginitis & cervicitis — itching, pain, increased discharge, odor 📈 Market reality Gynecological inflammation affects 70%–90% of married women (WHO survey). Rising incidence year by year. Vaginitis 42% 42% PID 35% 35% Vulvitis 13% 13% Cervicitis 4% 4% Others 6% 6% Common symptoms: itching, abnormal discharge, odor, swelling, painful intercourse, pelvic heaviness. 💔 The hidden struggle Main culprits: Candida, Trichomonas, Mycoplasma. Traditional antibiotics kill both pathogens and protective flora, breaking vaginal pH balance. 🌸 Healthy acidic pH 3.8–4.5 🌿 protects Lactobacillus ⚠️ Alkaline → overgrowth 🚫 Stop these harmful habits Harsh feminine washes — destroy microbiome Overusing medications — liver & kidney stress Ignoring symptoms — recurrent infections 🌸 Intimate skin is more sensitive than the eye area — treat it gently. 💧 Medical gel at a glance 📦 Specification 3g/stick · 5 sticks per box 🛡️ Mechanism Physical isolation barrier Forms a protective gel film on the vaginal wall — physically blocks pathogen colonization without killing beneficial bacteria. 🧾 Medical Device Registration No.: E-Record 20252185862 (Hubei) 🏭 Production License: E-Medical Device Production License 20231235 👩‍⚕️ Indicated for: Adjuvant treatment of itching, pain, leukorrhea, odor caused by vaginitis & cervicitis. 🌿 So, what should...

  • Heyuan Biotechnology | Bebevisa Skincare Solutions at Vietnam Medi-Pharm Expo 2026
    August 1, 2026

    From July 30 to August 1, 2026, the 24th Vietnam Medi-Pharm Expo 2026 was successfully held in Ho Chi Minh City, Vietnam. Heyuan Biotechnology (Ezhou) Co., Ltd. participated in the exhibition with its biotechnology-based beauty and medical skincare solutions, presenting innovative products developed through its Bebevisa Biotechnology Manufacturing Facility . During the exhibition, Heyuan Biotechnology connected with international distributors, beauty industry professionals, and potential partners from different countries, showcasing its capabilities in biotechnology research, product development, and manufacturing. Through this international platform, Heyuan Biotechnology demonstrated its expertise in recombinant collagen, exosome skincare, anti-aging solutions, and professional beauty products. Bebevisa Biotechnology Manufacturing Facility Showcases Innovative Beauty Solutions The products displayed at the exhibition were developed and manufactured through Bebevisa Biotechnology Manufacturing Facility, a professional production platform under Heyuan Biotechnology. The showcased product categories include: Recombinant Collagen Products Advanced biotechnology solutions designed for skin repair, hydration, and anti-aging applications. Exosome-Based Skincare Solutions Innovative skincare products utilizing next-generation biotechnology ingredients. Anti-Aging and Skin Repair Products Professional skincare solutions developed for global beauty markets. Medical Aesthetic Care Products Professional solutions for beauty clinics, aesthetic centers, and brand partners. By combining biotechnology research, advanced formulation development, and strict quality management systems, Heyuan Biotechnology continues to create effective and reliable skincare solutions for global customers. Professional OEM/ODM Skincare Manufacturing Solutions Heyuan Biotechnology (Ezhou) Co., Ltd. is...

  • That “squeak” is the sound of your skin barrier breaking down.
    May 16, 2026

    The Misconception: Clean ≠ Tight If your face feels “tight” after washing, you’re not cleansing—you’re stripping your skin. Across Southeast Asia, from Kuala Lumpur to Manila, this misunderstanding is everywhere. Consumers are chasing that “squeaky clean” feeling. But in reality: That “squeak” is the sound of your skin barrier breaking down. The Problem: Harsh Cleansers in Disguise Many mass-market cleansers rely on: Aggressive surfactants High-foam formulations Short-term “clean” sensation Packaged well—but fundamentally: 👉 They behave like detergents, not skincare. In hot, humid climates, this leads to: Barrier damage Increased sensitivity Oil imbalance (overproduction rebound) The Solution: A Bio-Active Cleansing System At Optical Valley, we took a different approach. Instead of asking “how strong is the cleanse?”, we asked: “How can cleansing support the skin ecosystem?” The Product: TuJiNi Purifying Cleansing Mousse This is not just a cleanser.It’s the first step of a complete skin-repair system. Core Formulation Technology Amino Acid Cleansing System 15 types of high-purity amino acids Gentle yet effective impurity removal Maintains natural skin barrier integrity Botanical Bio-Active Infusion Rosa Rugosa Flower Water (sourced from Japan & Indonesia) Centella Asiatica Extract These ingredients work together to: Calm the skin during cleansing Support hydration and repair Reduce post-wash irritation pH-Balanced, Barrier-Respecting Unlike traditional cleansers, this formula: Works in harmony with skin’s natural pH Avoids disruption of the microbiome Leaves...

  • The Shift from Cosmetic to Clinical: Why High-Tech HPV Care Is Redefining the Market
    May 16, 2026

    Market Reality: Fatigue Is Driving Change I was reviewing feedback from a clinic in Bangkok this morning, and one message came through clearly: Patients are exhausted. They are tired of: Being told to “just wait” Using so-called “cleansing waters” that don’t address real viral challenges Products that feel good—but do nothing measurable In Southeast Asia, the gap between cosmetic care and clinical-grade HPV solutions remains massive. And the truth is: Most products on the market are still built on scent and storytelling—not science. A Different Approach: Built for Clinical Credibility At Optical Valley, we didn’t spend five years in the lab to create another “pretty bottle.” We focused on one objective: Develop a Class II Medical Device that delivers real biological function. Our Anti-HPV Biological Protein Dressing is engineered using: High-purity recombinant protein technology Sterile production systems Controlled micro-environment support This isn’t about surface-level cleansing. It’s about: ✔ Supporting the cervical micro-ecosystem✔ Creating a controlled, protective biological environment✔ Enabling precision repair at the cellular level The Industry Gap: Cosmetic vs Clinical Cosmetic Products Clinical-Grade Solutions Focus on freshness & scent Focus on biological function Short-term comfort Long-term micro-ecological balance Low barrier to entry High regulatory & technical barrier Marketing-driven Evidence-driven For Distributors & Clinics: A Strategic Question If you are operating in markets like Vietnam or the Philippines, it’s time...

  • Most Rose Waters Are Just Scented Water — Here’s What Real Hydrosol Looks Like
    May 16, 2026

    I was speaking with a spa director in Ho Chi Minh City last week, and she didn’t sugarcoat it:“Most rose waters are just scented water.” She’s right — and it points to a deeper transparency problem in the skincare industry. What many brands label as “rose water” is often nothing more than diluted fragrance. It smells pleasant, but delivers little to no biological value. True rose hydrosol is different.It is the condensate collected during essential oil distillation — the pure, water-soluble fraction of the plant. This is where the real actives live: organic acids, trace micro-essential oils, and bio-compatible compounds that the skin can actually absorb. But here’s the catch:Producing authentic hydrosol is expensive, technically demanding, and difficult to stabilize. That’s why most suppliers avoid it. At TuJiNi, we chose the harder path. At our Optical Valley laboratories, our goal wasn’t to create a fragrance — it was to build a bio-active reservoir for the skin. Our TuJiNi Rose Hydrosol is: 100% natural distillation-derived Alcohol-free Fragrance-free Preserved through sterile, GMPC-compliant processes No shortcuts. No dilution. No synthetic enhancement. What you get is a formulation rich in naturally occurring actives — designed not just to sit on the skin, but to integrate with it. In high-end markets like Singapore and Thailand, sophistication is shifting.It’s no longer just about what ingredients you...

  • Reframing Anti-Aging: From Retinol Burnout to Structural Skin Recovery
    May 16, 2026

    In a recent conversation with a dermatologist in Bangkok, one topic came up almost immediately: “Retinol burnout.” In Southeast Asia, where UV exposure is consistently high, retinol-based routines often come at a cost. While clients seek firmness and visible anti-aging results, many are unwilling—or unable—to tolerate the irritation, peeling, and sensitivity that frequently follow. This tension is reshaping the premium skincare landscape. Increasingly, the luxury segment is turning toward Pro-Xylane—not as a trend, but as a more biologically aligned approach to skin aging. But here lies the deeper issue: Most products labeled “anti-aging” are, in reality, little more than heavy moisturizers. They hydrate—but they do not rebuild. For distributors and clinic owners, continuing to rely on such products leads to diminishing differentiation and shrinking margins. What the market truly demands is a solution that addresses the structural foundation of the skin. At TuJiNi, we approached this challenge from a different angle. Developed across our Optical Valley and French laboratories, our Pro-Xylane Firming Cream is built around a stabilized bio-active delivery system. Rather than focusing on surface-level effects, it works by stimulating the production of glycosaminoglycans (GAGs)—key components responsible for maintaining skin density, elasticity, and hydration at a structural level. Our formulation combines: Stabilized Pro-Xylane Brazilian Mauritia Flexuosa Fruit Oil Collagen Carnosine Together, these components help reinforce the skin’s internal scaffolding—restoring...

Our Core Solutions

Konjac Sponge Manufacturer in China

OEM & wholesale manufacturing of natural konjac sponge products for global skincare brands.

OEM Konjac Sponge Supplier

Private label manufacturing with custom packaging and branding solutions.

What is Konjac Sponge

Learn about benefits, uses, and natural skincare applications.

Frequently asked questions

What is your MOQ for private label konjac sponges?

Standard MOQ starts from 1,000 pieces per design; custom shapes or colors may vary. We confirm the exact MOQ together with your quote.

Do you provide free samples?

Yes. Stock samples are free — you only cover the courier. Customized samples are quoted separately and refundable upon order.

What is the lead time for bulk orders?

Typically 30-45 days depending on the level of customization and the season. Rush options are available for repeat orders.

Which certifications do you hold?

ISO 9001, ISO 22716, ISO 13485 and GMPc, plus CMA, FDA registration and Intertek testing reports.

Can you do custom packaging and logo?

Yes — printing, embossing, laser engraving and FSC-certified eco packaging are all available in-house.